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KMID : 1098420160240010038
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Korean Journal of Medicinal Crop Science
2016 Volume.24 No. 1 p.38 ~ p.46
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Whitening and Anti-Wrinkle Effects of Tremella Fuciformis Extracts
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Lee Kwang-Ho
Park Hyun-Soo
Yoon Il-Joo
Shin Young-Bong
Baik Young-Chan
Kooh Dae-Ho
Kim Sung-Kew
Jung Ho-Kyung
Sim Mi-Ok
Cho Hyun-Woo
Jung Won-Seok
Kim Myoung-Seok
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Abstract
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Background : The white jelly mushroom (Tremella fuciformis), one of the most popular edible fungi, has medicinal properties. However, the effects of T. fuciformis in skin whitening or anti-wrinkle efficacy has not been defined to date. The aim of the present study was to investigate the effects of T. fuciformis extracts on whitening and anti-wrinkle efficacy in skin cells.
Methods and Results : We prepared T. fuciformis extracts with water. The extracts (80℃) contained 12.11 ㎎/g polyphenol and 8.54 ㎎/g flavonoid concentration. T. fuciformis extracts markedly decreased melanin contents and tyrosinase activity in α-MSHstimulated melanocytes (B16F10 cells). In addition, the mRNA expression of melanin formation factors, such as microphthalmiaassociated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) were significantly down-regulated in α-MSH-stimulated melanocyte. Furthermore, T. fuciformis extracts increased the synthesis of type I procollagen and reduced mRNA expression of matrix metalloproteinase 1 (MMP-1) in the human dermal fibroblast (HDFn cells). These data indicated that T. fuciformis extracts induce repression of cellular melanogenesis and protect against wrinkles caused by UVB-stimulated damage.
Conclusions : Thus T. fuciformis extracts could be a cosmetic candidate for skin whitening and anti-wrinkle effects.
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KEYWORD
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Tremella fuciformis, Anti-Wrinkle, Collagen, Melanin, Natural Product, Whitening
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